Many here have expressed skepticism at GLP1s because they don't require the personal discipline of caloric deficit and might have unknown side effects.
So far, all the unknown side effects I've read about have been like this.
N of 1, but I had serious low drive/motivation side effects from Wegovy. Everything enjoyable became less enjoyable, from alcohol, to running, and after a couple of months, even getting out of bed. I lost weight slower than I had previously with old school calorie counting (most of which I have kept off to this day). Within a couple weeks of getting off it I was back to normal.
My conspiracy theory is that a lot of people must be getting this global lowered reward sensitivity from GLP-1s but are ignoring the negative sides of that effect because they like being skinny.
> My conspiracy theory is that a lot of people must be getting this global lowered reward sensitivity from GLP-1s but are ignoring the negative sides of that effect because they like being skinny.
Possibly some of them could also be unintentionally countering the impacts through things like self-medicating with caffeine.
I have no personal experience with GLP-1s but suddenly quitting caffeine after decades of daily use was pretty eye-opening in terms of how much it was boosting my baseline mood. And I'm not talking about being cranky for a couple of days after quitting, I'm talking about a very noticeable sustained change from when I was a frequent caffeine user to when I stopped having it altogether.
It's not the caloric deficit, it's the insulin. Cells don't have caloric receptors, only insulin receptors. I created an info site about this. Managing your insulin have the same effects as GLP-1 meds.
> Vadim Gladyshev, a Harvard biologist who assisted Novo with its molecular measurements, said: "In an unhealthy population, I do think it's an anti-aging drug. But in a healthy population, no one knows."
I'm glad the article actually said what we're all thinking. It makes perfect sense that managing blood glucose and a healthier diet/weight would "slow biological aging" regardless of how it was done.
I'm only skeptical of GLP-1 because it seems unnecessary, but if it helps some people I guess it's their choice.
Many here have expressed skepticism at GLP1s because they don't require the personal discipline of caloric deficit and might have unknown side effects.
So far, all the unknown side effects I've read about have been like this.
Lawsuits claiming Ozempic, other GLP-1s led to blindness become second mass litigation over the drugs
https://www.reuters.com/legal/government/lawsuits-claiming-o...
This is from a year ago. Millions of people are on GLP-1s, there's definitely not a mass blindness that's ongoing.
Not to mention the first people on these drugs were type 2 diabetics who are the exact group that's at risk for NEON.
Think of all the things they're not gonna be at risk for, not being diabetic now.
I’ve seen headlines about a potential link to hair loss lately.
N of 1, but I had serious low drive/motivation side effects from Wegovy. Everything enjoyable became less enjoyable, from alcohol, to running, and after a couple of months, even getting out of bed. I lost weight slower than I had previously with old school calorie counting (most of which I have kept off to this day). Within a couple weeks of getting off it I was back to normal.
My conspiracy theory is that a lot of people must be getting this global lowered reward sensitivity from GLP-1s but are ignoring the negative sides of that effect because they like being skinny.
> My conspiracy theory is that a lot of people must be getting this global lowered reward sensitivity from GLP-1s but are ignoring the negative sides of that effect because they like being skinny.
Possibly some of them could also be unintentionally countering the impacts through things like self-medicating with caffeine.
I have no personal experience with GLP-1s but suddenly quitting caffeine after decades of daily use was pretty eye-opening in terms of how much it was boosting my baseline mood. And I'm not talking about being cranky for a couple of days after quitting, I'm talking about a very noticeable sustained change from when I was a frequent caffeine user to when I stopped having it altogether.
It's not the caloric deficit, it's the insulin. Cells don't have caloric receptors, only insulin receptors. I created an info site about this. Managing your insulin have the same effects as GLP-1 meds.
Why mention your info site without providing a link? It's a little frustrating to read comments like this. Thank you.
> Vadim Gladyshev, a Harvard biologist who assisted Novo with its molecular measurements, said: "In an unhealthy population, I do think it's an anti-aging drug. But in a healthy population, no one knows."
I'm glad the article actually said what we're all thinking. It makes perfect sense that managing blood glucose and a healthier diet/weight would "slow biological aging" regardless of how it was done.
I'm only skeptical of GLP-1 because it seems unnecessary, but if it helps some people I guess it's their choice.
Sign me up for this miracle drug already.
I suspect that there's twice as many people taking RUO versions of it than actual prescriptions.
You can get the stuff at a mall kiosk now.
Now I just gotta find a mall kiosk. Maybe a time machine would help.
Related:
GLP-1 may slow biological aging
https://news.ycombinator.com/item?id=50132328
TLDR; being fat accelerates aging