15 comments

  • woliveirajr an hour ago

    Sildenafil [0] was synthesized to treat high blood pressure. Erectile disfunction was a side effect that raised much more interest.

    Tadalafil [1] followed the path of Sildenafil about the phosphodiesterase type 5 (PDE5) enzyme inhibitor.

    Help to live longer was the main objective since the beginning.

    [0] https://en.wikipedia.org/wiki/Sildenafil#History [1] https://en.wikipedia.org/wiki/Tadalafil#History

    • joezydeco 36 minutes ago

      I invested heavily in ICOS when they launched, they had Bill Gates money and were looking for ways to extend lifespans and solve inflammation.

      And all we got was another boner pill.

      • fny 30 minutes ago

        Lifespans and inflammation are ironically harder problems.

      • fragmede 25 minutes ago

        During your extended lifetime, wouldn't you like to be able to have a boner, though?

  • comrade1234 43 minutes ago

    The weirdest thing I read about was weightlifters taking viagra to increase their blood flow when working out at the gym. Hopefully they shower at home.

    • GenerWork 36 minutes ago

      >weightlifters taking viagra to increase their blood flow when working out at the gym

      The weightlifting community moved off of Viagra years ago due to Cialis having a much longer half life.

  • jurip 18 minutes ago

    There was also just last week this study, which indicated a link to a higher risk of glaucoma: https://www.thepharmacist.co.uk/clinical/mens-health-clinica...

  • francisofascii 32 minutes ago

    Suprised this article doesn't mention nitric oxide or vasodilation? Is that how it works. It boosts nitric oxide signaling, acts as a vasodilator, and improves endothelial function. Beet juice, exercise, and eating nitrate-rich vegetables are some non-pharmaceutical ways to have a similar effect.

  • jacknews an hour ago

    Maybe the extra sex is the main benefit?

    • Geof25 37 minutes ago

      Monkey paw wish - you will live longer, but you will be constantly erect.

      • MarkusQ 32 minutes ago

        Would that be a hard choice?

        • busterarm 17 minutes ago

          Might be the hardest.

    • brandonb an hour ago

      Can't rule out exercise.