That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
Can you point me to anything about mitochondrial transplants? I'd love to see bat mitochondria transplanted into other mammals. They must have really superior ones given the energy expenditures needed to support flight and their long lifespans.
When the damage accumulates across generations the natural selection has opportunity to weed out particularly harmful instances. You can get a feeling for how important avoiding the mitochondrial damage is and how hard it is to mitigate, by looking at how fiercely the reproductive process protects them from aging.
Guess the japanese excel at micromanaging. Although one could
say that the research here in the article is more epic than
Shinya's discovery, but I remember having watched one of his
presentation and it convinced me of pure epicness, if you
understand how his team found the "Yamanaka factors". That
was by human (work) consistency. About as epic as
Christiane Nüsslein-Volhard and her mutant screens, that also
involved tons of micro-experiments.
Related (2021) Turning stem cells into human eggs (97 points, 102 comments) https://news.ycombinator.com/item?id=29040823
How hard you have to work to break scroll on web page? Nice article, but going through it was a technical nightmare.
Can we stop adding unnecessary JS to website to stop global warming by calculating AND ALTERING SCROLL?
Odd. It was a designers dream (and a readability nightmare) but I didn't have an issue with scroll.
Firefox on Samsung S23, not exactly a new or a powerful phone but rendered it fine.
Good idea in theory but terribly impractical in practice.
That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
I wonder if you could coax cells from the testes back into stem cells to then re-specialize into ovarian cells.
Mitochondria can be translplanted/replaced. There already therapies and babies born out of these kinds of procedures
Can you point me to anything about mitochondrial transplants? I'd love to see bat mitochondria transplanted into other mammals. They must have really superior ones given the energy expenditures needed to support flight and their long lifespans.
I will let the experts continue from here :) This review is from 2020, i bet things have progressed since then
https://pmc.ncbi.nlm.nih.gov/articles/PMC7169912/
Really interesting point if true. Makes sense to me, and I’m sure the team is trying to solve it
genuinely curious: how does any life still exist if this holds true?
When the damage accumulates across generations the natural selection has opportunity to weed out particularly harmful instances. You can get a feeling for how important avoiding the mitochondrial damage is and how hard it is to mitigate, by looking at how fiercely the reproductive process protects them from aging.
A japanese scientist again (Katsuhiko Hayashi is in Osaka).
Shinya Yamanaka created iPSPs in 2009:
https://en.wikipedia.org/wiki/Shinya_Yamanaka
Guess the japanese excel at micromanaging. Although one could say that the research here in the article is more epic than Shinya's discovery, but I remember having watched one of his presentation and it convinced me of pure epicness, if you understand how his team found the "Yamanaka factors". That was by human (work) consistency. About as epic as Christiane Nüsslein-Volhard and her mutant screens, that also involved tons of micro-experiments.