New protein therapy shows promise as antidote for carbon monoxide poisoning

(medschool.umaryland.edu)

120 points | by breve 4 hours ago ago

28 comments

  • narrator 3 hours ago

    Methylene blue works great, is very cheap, and it's been around for over a century. I guess I shouldn't be a hater. This seems to improve the effectiveness of existing treatments. However, shame they don't mention methylene blue though in the article.

    • Herodotus38 28 minutes ago

      Hello, I would be interested if you could give evidence that methylene blue "works great" for carbon monoxide poisoning in humans.

      It is not the standard of care in any guidelines I can find from any country. There is a paper from 2018 out of china showing some benefit in a rat model: https://onlinelibrary.wiley.com/doi/10.1111/bcpt.12940

    • gus_massa 2 hours ago

      IANAMD I made a quick search and the evidence of methylene blue as a carbon monoxide antidote looks controversial.

      IIUC part of the effect is oxidizing/reducing the iron atom in the hemoglobin, and that changes how strong is the bound with the O2, CO, NO. But my chemistry is not enough to give a good guess of the results.

    • majkinetor 3 hours ago

      God forbid we have alternatives that work in minutes

      • lagniappe 35 minutes ago

        Given that MB is commonly supported by those with right leaning politics, it won't be reported on for risk of appearing to support the "wrong" party.

        • darth_avocado 4 minutes ago

          Why would a treatment be not made available if it’s effective? What’s the conspiracy in letting people suffer and die?

        • jayd16 7 minutes ago

          It's been around for a century but it's a political conspiracy to keep it unknown??

        • Traubenfuchs 25 minutes ago

          Awful.

          Reminds me how ivermectin was approached during the covid pandemic. No, it did not help against covid, but it did prevent people with strongyloidiasis receiving corticosteroids for covid from almost certain death.

          Instead of ridiculing the people taking it, trying to prevent them taking it and strengthening conspiracy theories, from a public trust and health perspective, people should have been advised in how to safely take it, if they really wanted to.

          From those perspective you sometimes have to work with idiots, not try to fight them. Same with the vaccinations: "hey, this vaccine might prevent you from a disease that could kill you, especially if you are fat, old and male -you SHOULD take it, but you don't have to" we got an absolutely diabolical "you will leave your job and won't be allowed to leave the house if you don't get vaccinated" laws.

          • jrajav 18 minutes ago

            "hey, speeding down the highway 35mph over the limit could kill you, especially if you are fat and old. you SHOULD drive under the speed limit, but you don't have to."

            No, the point is that it could kill other people. Speed all you want when you're on your own private roads.

            Laws are generally meant to ensure public safety and the ability for us to live and cooperate together with mutual trust. They usually do end up restricting your personal freedoms to that end. Deal with it.

          • tekno45 14 minutes ago

            health officials shouldn't have to work around the fucking president pulling conspiracies out their ass.

    • EvanAnderson 3 hours ago

      Methylene blue has a fun/shocking side-effect.

  • searine 36 minutes ago

    This research was funded by multiple NIH grants, a Department of Defense grant, and the Martin Family Foundation.

  • dtgriscom an hour ago

    How is this administered? Seems like a crucial detail to omit.

    • elric 39 minutes ago

      > This has the potential to become a rapid, intravenous antidote for carbon monoxide

      So intravenously, presumably.

    • DonHopkins an hour ago

      You can spread it on bread, melt it over pancakes, rub it all over corn on the cob, put it in baked potatoes, etc, promise!

  • bananapub 2 hours ago

    not very on topic, but for those who missed one of the more surreal reddit threads in history:

    - [MA] Post-it notes left in apartment [0]

    - and the update from OP a while later [1]

    [0]: https://www.reddit.com/r/legaladvice/comments/34l7vo/ma_post...

    [1]: https://www.reddit.com/r/AskReddit/comments/49zfvb/what_is_t...

    • gus_massa an hour ago

      It looks like he found a note in his room and see some strange thing in the window, and someone somehow says it's CO but it may be that the OP has unrelated hallucinations. Is this a symptom of CO poisoning? I think you only get sleepy, faint and die.

      • hinkley an hour ago

        CO exposure is accumulative. If you’re around an intense source of it you’re toast. But with a small point source or decent ventilation it kills you slower.

        And your body produces new blood cells every day, so minor sources like wood smoke or burning a candle don’t dose you enough to be a problem, unless perhaps your day job is as an athlete.

      • maxbond an hour ago

        Chronic exposure can lead to memory loss, yes. You're describing the symptoms of acute exposure.

  • DonHopkins 3 hours ago

    >New Protein Therapy Shows Promise as Antidote for Carbon Monoxide Poisoning

    So Shatner was right all along: not only is Promise Margarine good for lowering your cholesterol level, but it can also treat carbon monoxide poisoning! And it tastes like butter, promise.

    https://www.youtube.com/watch?v=n3wf717fKFE

    • majkinetor 3 hours ago

      I don't see a relation of any kind and I hate commercials maybe more than anybody else, but it's always a good time for a funny one with Shatner :)

      • DonHopkins an hour ago

        Sheez, I can't believe I have to explain that Shatner shows Promise as antidote for high cholesterol too.