There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2].
There is a number of disease models that show reduced or no glymphatic clearance and as such these people need treatments to clear out their brains and these image routines seem to help. A lot of people find this pattern extremely taxing to watch especially for the recommended number of cycles, you can feel the effect on the brain its hard to describe the sensation its a bit numbing and the image has the sensation of changing as the cycle runs like its a visual trick. You might get left feeling like you have been clubbed over the head the first time.
I find it interesting this is one aspect of disease research I am looking into and is related to Long Covid and ME/CFS.
From the paper, it seems like that the blood flow changes and the seizures are both caused by the increased processing load in the visual cortex; with the seizures also resulting from some faulty wiring in localizing that increased load to only the visual cortex.
So, more like A->B and A->C instead of A->B->C.
But I'd bet this visual stimuli is even more effective at causing seizures in vulnerable people than an unfortunate pokemon episode.
It's taken 12 years to get from "this stuff exists in mice" to "we now know it actually exists in humans and is not vestigial". That seems like a long time. People get brain MRIs with contrast all the time, is there any reason why this never showed up? Because no one was looking? Or because it's a slow mechanism?
Looking up “brain MRI with contrast”, the biggest difference seems to be that in a regular MRI the contrast goes to the blood, but here it goes straight to the brain cerebrospinal fluid. You need open brain for that, so indeed doesn’t seem trivial.
There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2].
There is a number of disease models that show reduced or no glymphatic clearance and as such these people need treatments to clear out their brains and these image routines seem to help. A lot of people find this pattern extremely taxing to watch especially for the recommended number of cycles, you can feel the effect on the brain its hard to describe the sensation its a bit numbing and the image has the sensation of changing as the cycle runs like its a visual trick. You might get left feeling like you have been clubbed over the head the first time.
I find it interesting this is one aspect of disease research I am looking into and is related to Long Covid and ME/CFS.
[1] https://journals.plos.org/plosbiology/article?id=10.1371/jou...
[2] https://www.paulkeeble.co.uk/posts/cff/
This is some amazing work; and it also raises my belief that a Langford Basilisk is neurologically possible by about 25%
I think I must have turned off repetitive play in browser. wonder if there is an m4v version
Holy cow.... that's really rough, you weren't kidding.
This is the closest I've ever felt to being a Borg.
This is fascinating.
Curious, could seizures caused by strobe light be related to the effects of draining of this fluid?
From the paper, it seems like that the blood flow changes and the seizures are both caused by the increased processing load in the visual cortex; with the seizures also resulting from some faulty wiring in localizing that increased load to only the visual cortex. So, more like A->B and A->C instead of A->B->C. But I'd bet this visual stimuli is even more effective at causing seizures in vulnerable people than an unfortunate pokemon episode.
For the cff page on Safari, create a bookmarklet to make it go pure full screen:
javascript:document.documentElement.webkitRequestFullScreen();
It's taken 12 years to get from "this stuff exists in mice" to "we now know it actually exists in humans and is not vestigial". That seems like a long time. People get brain MRIs with contrast all the time, is there any reason why this never showed up? Because no one was looking? Or because it's a slow mechanism?
Looking up “brain MRI with contrast”, the biggest difference seems to be that in a regular MRI the contrast goes to the blood, but here it goes straight to the brain cerebrospinal fluid. You need open brain for that, so indeed doesn’t seem trivial.